HBV-Related Hepatocellular Carcinoma Susceptibility Gene KIF1B Is Not Associated with Development of Chronic Hepatitis B

A recent genome-wide association study has identified a new susceptibility locus, kinesin family member 1B gene (KIF1B), strongly associated with progression from chronic hepatitis B (CHB) to hepatitis B virus-related hepatocellular carcinoma (HCC) in Chinese population, this study was carried out to explore the role of the genetic variants in KIF1B in the development of chronic hepatitis B.Three KIF1B polymorphisms (rs8019, rs17401924, and rs17401966) were selected and genotyped in 473 CHB patients and 580 controls with no history of CHB. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by logistic regression model. None of these three SNPs showed association with CHBs after adjusting for age and gender. Equivalence-based method analysis confirmed the absence of association. In the further haplotype analysis, three common haplotypes were observed in this study population, but no significant effect was also found for haplotypes in the progression to CHB.This study showed the new locus identified for HCC, KIF1B, was not associated with progression to CHB, implying distinct genetic susceptibility factor contributes to the progression from hepatitis B virus infection to HCC. Nevertheless, further comprehensive analyses are warranted to dissect the mechanism

SPIHT Algorithm with Huffman Encoding for Image Compression and Quality Improvement over MIMO OFDM Channel

In this paper, Compression and improving the Quality of images during the transmission using SPIHT algorithm combined with Huffman encoding over OFDM channel has been proposed. Initially decompose the image in to different level, the compressed coefficients are arranged in descending order of priority and mapped over the channels. The coefficients with lower importance level, which are likely to mapped over the bad sub channels, are discarded at the transmitter to save power without significant loss of reception quality. Next SPIHT embedded encoder algorithm combined with Huffman encoder is applied for further compression. Finally the Huffman and SPIHT decoding of the embedded encoder is done. In this technique reduce the number of encoding bits and improving the Quality of image

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Not AvailableNot AvailableVietnam Academy of Agricultural Sciences (VAAS

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Not AvailableIET 18006 is an elite Basmati variety, with highly desirable long slender grain type and medium duration and possesses excellent aroma. However, the variety is highly susceptible two major diseases, viz., bacterial blight (BB) and blast which reduce yield of the elite Basmati variety significantly. We have improved IET 18006 through targeted introgression of the major BB resistance genes, Xa21 and xa13 and the major blast resistance gene, Pi54 through marker-assisted backcross breeding (MABB). The elite variety, Improved Samba Mahsuri (ISM) possessing bacterial blight resistant genes Xa21 and xa13 and a Vietnamese variety, Tetep possessing blast resistant gene, Pi54 were used as donor parents for improvement of IET 18006 through two sets of backcrosses and backcrossing was continued till BC2 generation. At each backcross generation, plants possessing Xa21, xa13 and Pi54 in heterozygous condition were identified with help of gene-specific markers through foreground selection; while a set of parental polymorphic SSR markers were used for background selection. At BC2F2, a promising backcross plant possessing Xa21 + xa13 was intermated with a backcross plant possessing Pi54 to generate intercross F1s (i.e. ICF1s), which were then selfed. At ICF2 generation, plants which possessing Xa21 + xa13 + Pi54 in homozygous condition were identified with the help of gene specific markers and advanced further through selfing. At ICF4¬, four promising three-gene pyramid lines of IET 18006 possessing high level of resistance against both BB and blast along with high yield and grain type similar to the recurrent parent were identified.Not Availabl

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Not AvailableBacterial blight (BB) disease reduces the yield of rice varieties and hybrids considerably in many tropical rice growing countries like India. The present study highlights the development of durable BB resistance into the background of an elite maintainer of rice, DRR17B, by incorporating two major dominant genes, Xa21 and Xa33 through marker-assisted backcross breeding (MABB). Through two sets of backcrosses, the two BB resistance genes were transferred separately to DRR17B. In this process, at each stage of backcrossing, foreground selection was carried out for the target resistance genes and for non-fertility restorer alleles concerning the major fertility restorer genes Rf3 and Rf4, using gene-specific PCR-based markers, while background selection was done using a set of 61 and 64 parental polymorphic SSR markers respectively. Backcross derived lines possessing either Xa21 or Xa33 along with maximum genome recovery of DRR17B were identified at BC3F1 generation and selfed to develop BC3F2s. Plants harboring Xa21 or Xa33 in homozygous condition were identified among BC3F2s and were intercrossed with each other to combine both the genes. The intercross F1 plants (ICF1) were selfed and the intercross F2(ICF2) plants possessing both Xa21 and Xa33 in homozygous condition were identified with the help of markers. They were then advanced further by selfing until ICF4 generation. Selected ICF4 lines were evaluated for their resistance against BB with eight virulent isolates and for key agro-morphological traits. Six promising two-gene pyramiding lines of DRR17B with high level of BB resistance and agro-morphological attributes similar or superior to DRR17B withcomplete maintenance ability have been identified. These lines with elevated level of durable resistance may be handy tool for BB resistance breedingNot Availabl